J Med Life Sci > Volume 12(1); 2015 > Article
Journal of Medicine and Life Science 2015;12(1):20-22.
DOI: https://doi.org/10.22730/jmls.2015.12.1.20    Published online December 18, 2018.
약물에 의한 심혈관계 부작용
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Drug-induced cardiovascular disorders
Eunkyoung Lee, Jaechun Lee, HyeJung Han
Correspondence:  Jaechun Lee,
Abstract
Adverse drug reactions (ADRs) affecting cardiovascular system might be underestimated and underreported in clinical practice. Most common culprit drugs are anthracyclines, antipsychotics and cyclooxygenase (COX)-2 inhibitors. Anthracyclines may induce myocardial damage with oxidative stress, which is mostly irreversible. Type I ADRs are commonly encountered in antipsychotic use. Attention should be paid to the risk of sudden cardiac death related to some antipsychotics. COX inhibitors pharmacologically have antithrombotic activities. However, in COX2 selective inhibitors, myocardial infarction and stroke might be induced paradoxically.
Key Words: Adverse drug reaction, Cardiovascular system, Cardiovascular diseases
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