| 별아교세포에서 NMDA 수용체 길항제의 칼슘흥분성 조절 기능 |
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| Modulatory function of calcium excitability in astrocytes by
NMDA receptor antagonists |
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Dash Oyunbileg, Joo-Min Park, Su-Yong Eun, Sung-Cherl Jung |
Correspondence:
Sung-Cherl Jung,
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| Abstract |
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Astrocytes, the predominant cell type in central nervous system, are electrically non-excitable cells. However, astrocytes
display their excitability by increasing intracellular calcium concentration. Several lines of evidence have highlighted the
importance of astrocytic calcium excitability in both physiological and pathological conditions. Here, we investigated the effects
of dissociated anesthetics: ketamine and MK-801 (dizocilpine) known as NMDA (N-methyl-D-aspartate) receptor antagonists, on
calcium excitability in mouse cortical astrocytes. We further compared the effects of Ketamine and MK-801 on astrocytic
serotonin (5-HT) receptors. In cultured cortical astrocytes, MK-801 increased intracellular calcium concentration and led to
further increases in calcium in the presence of 5-HT. However ketamine had no effect on the calcium response in astrocytes.
These results suggest that the calcium concentration in astrocytes is reinforced by MK-801 under the modulation of serotonin
receptors. |
| Key Words:
NMDA receptor, Astrocyte, Calcium, Serotonin receptor, Cerebral cortex |
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