J Med Life Sci > Volume 14(2); 2017 > Article
Journal of Medicine and Life Science 2017;14(2):62-66.
DOI: https://doi.org/10.22730/jmls.2017.14.2.62    Published online December 18, 2018.
External Application of Horse Oil Alleviates Atopic Dermatitis Symptoms in Mice
Sang-Hyun Yoon, Na-Jin Kang, Eun-Sook Yoo
Correspondence:  Eun-Sook Yoo,
Abstract
Atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. Horse oil, the purified form from horse fat, has been used for a long time by fork remedies on burn, wound, and various skin diseases. In this study, we investigated the improving effects of horse oil on atopic dermatitis induced by 0.3% of DNCB in mice. Horse oil B (oil phase, 100 mg/kg) significantly decreased serum IgE levels in experimental atopic dermatitis mice induced by DNCB. Also, horse oil A (cream phase, 100 mg/kg) and B alleviates atopic dermatitis symptoms (ear edema, inflammatory cell infiltration, and lymph node size). Overall, the effect of horse oil B was slightly better. These results suggest that horse oil can be a useful remedy to improve atopic dermatitis.
Key Words: Horse oil, Atopic dermatitis, 2, 4-Dinitrochlorobenzene, Immunoglobulin E
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