J Med Life Sci > Volume 16(3); 2019 > Article
Journal of Medicine and Life Science 2019;16(3):55-59.
DOI: https://doi.org/10.22730/jmls.2019.16.3.55    Published online January 16, 2020.
CADASIL 동물모델의 생리학적 접근 및 연구적 가치의 예측
정성철1, 고은아2
1제주대학교 의과대학 생리학교실
2미국 네바다 주립대학교 생리학/세포생물학 교실
Physiological approach of CADASIL animal model and its predictable implication
Sung-Cherl Jung1, Eun-A Ko2
1Department of Physiology, Jeju National University School of Medicine, Jeju, Republic of Korea
2Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, Nevada 89557, USA
Correspondence:  Eun-A Ko, Email: eko@med.unr.edu
Abstract
Cerebral vessels are functionally and structurally specialized to provide adequate blood flow to brain which shows high metabolic rates. Cerebral hemorrhage or ischemic infarction due to cerebrovascular injury or occlusion can cause the immediate brain damage, and if not treated rapidly, can lead to serious or permanent brain damages, and sometimes life-threatening. Unlike these popular cerebrovascular diseases, there are diseases caused by genetic problems. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of them. CADASIL does not show the high incidence, but it is considered to be significantly affected by regional obstructiveness such as islands and therefore, to be an important genetic disease in Jeju. This paper aims to summarize the possibility of animal model research that can provide preclinical data for CADASIL disease research and to evaluate its applicability in future research plans.
Key Words: CADASIL, Animal, model, Cerebral, blood
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