| 대장 샘종에서 MCM7 단백의 발현에 관한 연구 |
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맹영희 |
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제주대학교 의과대학 병리학교실 |
| Expression of MCM7 protein in colorectal adenomas |
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Young-Hee Maeng |
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Department of Pathology, College of Medicine, Cheju National University, Jeju 690-756, Korea |
Correspondence:
Young-Hee Maeng, Email: yhmaeng@cheju.ac.kr
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| Abstract |
Background
Recently, the role of minichromosome maintenance proteins (MCM2-7) as markers of cell proliferation in human tissues has been studied.
Aims: To investigate the use of MCM7 in differentiating the dysplasia of colorectal adenomas
Methods
Semiquantitative analysis of MCM7-positive epithelial cells was performed on upper, middle, and lower thirds of normal and adenomatous crypts, and adenocarcinomas.
Results
In normal colon, expression of MCM7 protein occurs in the basal third of colonic crypts with loss of the protein in the upper third. In tubular adenomas, the upper third of the crypts shows strong positivity, however, the middle and basal thirds reveal less strong reactions in low-grade dyplasia and only a few positive cells in high-grade dysplasia. Colorectal adenocarcinomas revealed an even distribution of MCM7 protein throughout the tumor with occasional lower expression in the deeper part of the tumor.
Conclusion
The patterns of MCM7 protein expression are different between normal colonic mucosa, tubular adenoma with low-grade dysplasia, tubular adenoma with high-grade dysplasia, and colorectal adenocarcinoma.
MCM7 protein may be a useful proliferation marker in tubular adenoma and warrants further evaluation as a complementary tool in the diagnosis of low-grade and high-grade dysplasias. |
| Key Words:
MCM7, colorectal adenoma, dysplasia |
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