| 지연성 운동장애에서 Aripiprazole의 역할에 대한 고찰 |
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김문두 |
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제주대학교 의과대학 정신과학교실，제주대학교 의과학 연구소 |
| Role of aripiprazole in treating medication induced tardive dyskinesia |
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Moon-Doo Kim |
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Departments of Psychiatry and Institute of Medical Science, Cheju National University School of Medicine, Jeju, Korea |
Correspondence:
Moon-Doo Kim, Email: mdkim66@cheju. ac.kr
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| Abstract |
Objectives
To review the effects of aripiprazole in treatment of medication induced tardive dyskinesa
Methods
Medline search was was performed using key words of 'aripiprazole' and 'tardive dyskinesia', we searched overall articles published between 2000 and 2008.
Result
Aripiprazole inhibits central dopaminergic neuron activity by a partial agonistic effects on presynaptic D2 dopamine autoreceptors and also acts as an antagonist at postsynaptic D2 dopamine receptors. Through this mechanism, aripiprazole exerts activity as a dopaminergic agonist in hypodopaminergic states, while acting as a dopamine antagonist when dopaminergic activity is increased. There is also evidence from basic science studies that aripiprazole causes D2 receptor up-regulation
Conclusions
It is plausible that aripiprazole, by virtue of its dopamine agonistic activity, can potentially normalize D2 dopamine receptor up-regulation, this properties may play a role in both prevention of the emergence of tardive dyskinesia and the treatment of Tardive dyskinesia. Double blind placebo-controlled studies would be needed to enlighten this issues. |
| Key Words:
Tardive Dyskinesia, Aripiprazole, Action mechanism. |
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