J Med Life Sci > Volume 9(1); 2012 > Article
Journal of Medicine and Life Science 2012;9(1):64-68.
DOI: https://doi.org/10.22730/jmls.2012.9.1.64    Published online June 30, 2012.
HaCaT 각질형성세포에서 interferon-gamma 에 의해 유도된 MDC 와 STATl signaling pathway 에 대한 rengyolone 의 억제 효과
강나진, 강경진, 한상철, 강희경, 유은숙
제주대학교 의학전문대학원 약리학교실
Rengyolone inhibits MDC/CCL22 expression and STAT1 signaling pathway induced by interferon-y in HaCaT keratinocyte
Na-Jin Kang, Gyeoung-Jin Kang, Sang-Chul Han, Hee-Kyoung Kang, Eun-Sook Yoo
Department of Pharmacology, Jeju National University School of Medicine, Jeju, Korea
Correspondence:  Eun-Sook Yoo, Email: eunsyoo@jejunu.ac.kr
Abstract
Rengyolone is a cyclohexylethanoid isolated from the Eurya emarginate (Thunb) Makino. lt has been shown to exhibit antibacterial activity, anti-inflammatory, and diuretic. The aim of this study was to investigate the effective and activated mechanism by which rengyolone inhibits IFN-γ-induced MDC expression in the human keratinocyte cell line HaCaT. We found that rengyolone dose dependently inhibited MDC production by lFN-γ stimulation in HacaT keratinocytes. Also rengyolone suppressed IFN-γ-induced phosphorylation of STAT1, a key transcription factor infiltrating IFN-γ signaling pathway. Therefore We propose that Rengyolone could be used as a basis therapeutic material against atopic dermatitis.
Key Words: rengyolone; HaGaT; MDC; interferon-y; STAT1
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