| Effect of Ecklonia Cava on glucose consumption in rat skeletal muscle cells |
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Jian Guan, Deok Bae Park |
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Department of Histology, Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Deok Bae Park, Email: parkdb@jejunu.ac.kr
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| Abstract |
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Ecklonia cava is a kind of brown sea algae and its extract has known to be anti-adipogenic, anti-inflammatory, and so on. However, It less has been known about the action mechanism in regulating glucose metabolism in skeletal muscle cells. The present study investigated the effect of the ethanol extract of Ecklonia cava (E-EC) on glucose consumption and its related signaling properties in L6 rat skeletal muscle cells. E-EC slimulated glucose consumption as well as the translocation of glucose transporter 4 (Glut4) from cytosol to plasma membrane in L6 muscle cells. E-EC also stimulated Pl3 kinase (PI3K)-dependent Akt activity, one of crucial signaling cascades for glucose uptake. Inhibition of PI3K suppresed E-EC-stimuated glucose consumption and Glut4 translocation. However, E-EC failed to stimulate AMPK. These results suggest that the extract of Ecklonia cava stimulates glucose consumption regardless insulin activity in skeletal muscle cells via PI3K- Akt pathway through stimulating Glul4 translocation to the plasma membrane. |
| Key Words:
Ecklonia cava; giucose; PI3 kinase; muscle |
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