J Med Life Sci > Volume 6(2); 2009 > Article
Journal of Medicine and Life Science 2009;6(2):92-97.
DOI: https://doi.org/10.22730/jmls.2009.6.2.92    Published online February 28, 2009.
가와사끼병에서 관상동맥 합병증의 발생 위험 인자로서의 Matrix metalloproteinases 의 유전자다형태
신경수
제주대학교 의학전문대학원 소아과학교실, 제주대학교 의과학연구소
Matrix metalloproteinase gene polymorphisms as a risk factor for coronary artery lesions in Kawasaki disease
Kyung-Sue Shin
Department of Pediatrics, Jeju National University School of Medicine, and Institute of Medical Science, Jeju National University College of Medicine, Jeju, Korea
Correspondence:  Kyung-Sue Shin, Email: kyungSue@jejunu.ac.kr
Abstract
Kawasaki disease (KD) is a multi-systemic vasculitis that leads to coronary artery damage and coronary artery lesions (CALs). Recent studies have demonstrated that patients with Kawasaki disease have elevated expression, activity, or serum level of matrix metalloproteinases (MMPs) and MMPs promoter polymorphisms modify each transcriptional activity in allele specific manner. Therefore, an evaluation of the genetic contributions of the MMP genes to the development of CALs in KD patients would be beneficial for the prediction of CAL formation. However , it remains unclear whether the tested MMP polymorphisms are associated with KD or CAL formation. To firmly estabtish the association between MMP polymorphisms and the development of CAL in KD, further large-scale studies are required in other populations.
Key Words: Matrix metalloproteinases, Genetic polymorphism, Coronary artery disease, Kawasaki disease
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