General consideration of drug hypersensitivity syndrome: Diagnosis and pathogenesis

Kim, Jae-wang; K0, Hye-Rim

doi:2009.6.2.98

J Med Life Sci > Volume 6(2); 2009 > Article

Journal of Medicine and Life Science 2009;6(2):98-103.
DOI: https://doi.org/10.22730/jmls.2009.6.2.98 Published online February 28, 2009.

약과민증후군의 개론 :진단 및 발병 기전

김재왕¹, 고혜림²

¹제주대학교 의과대학전문대학원 피부과학교실
²제주대학교 의과대학전문대학원 의학과

General consideration of drug hypersensitivity syndrome: Diagnosis and pathogenesis

Jae-wang Kim¹, Hye-Rim K0²

¹Department of Dermalology，Jeju National University School of Medicine, Jeju, Korea
²Department of Medical course，Jeju National University School of Medicine, Jeju, Korea

Abstract

Drug hypersensitivity syndrome(DHS) is a life-threatening reaction that appears after prolonged exposure to certain offending drugs. Unlike usual drug eruptions. DHS typically represents a protracted clinical course, slow resolution and higher mortality rate. Recently several studies have provided the evidence to show reactivation of human herpesvirus-6(HHV-6) implicated in the pathogenesis of DHS. Accordingly. it can not be excluded that HHV-6 reactivation might play a potential role in the development of DHS in susceptible patients.

Key Words: Drug hypersensitivity syndrome