J Med Life Sci > Volume 8(1); 2011 > Article
Journal of Medicine and Life Science 2011;8(1):8-11.
DOI: https://doi.org/10.22730/jmls.2011.8.1.8    Published online December 30, 2011.
Coxsackievirus B4 에 의해 발생한 제 1형 전격성 당뇨병 2예
유정래, 이상아, 고관표, 이대호
제주대학교 의학전문대학원 내과학교실
Fulminant type 1 diabetes associated with Coxsackievirus B4:A report of 2 cases
Jung Re Yu, Sang Ah Lee, Gwanpyo Koh, Dae Ho Lee
Department of Internal Medicine, School of Medicine, Institute of Medical Science, Jeju National University, Jeju, Korea
Correspondence:  Dae Ho Lee, Email: Ldhkso@jejunu.ac.kr
Fulminant type1 diabetes (T1 DM) has recently been identified as a new subtype of idiopathic diabeles, characlerized by rapid development of diabetes with no comorbidity of autoimmunity. Here, we report two cases of patients; each patient was presented with abrupt and extreme hyperglycemia and ketoacidosis without any evidence of previous diabetes mellitus. A 74-years-old man suffered from polydipsia for 2 days. At presentation, his serum C-peptide level was 0.06ng/ml, HbA 1c level was 6.7% and the serum Iipase was elevated. A 21-years-old man had polydipsia for 2 weeks. His serum C-peptide and HbA 1c levels were 0.73ng/ml and 17.6%, respectively. The serum lipase was normal. In both patients, anti-GAD antibody tests were negative, whereas tests for Coxsackievirus B4 virus infection were positive. Furthermore, insulin therapy is needed in both patients to control their blood glucose levels at discharges and during the follow-up period.
Key Words: fulminant diabetes; Coxsackievirus B4
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