| 성장단계의 흰쥐 해마 CAl 신경세포에서 안정막 전압과 세포용량 변화의 상관관계 |
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양윤실, 강문석, 김선희, 은수용, 정성철 |
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제주대학교 의학전문대학원 생리학교실 |
| The changes of neuronal capacitance related resting membrane potential of CA1 hippocampal neurons of rats in developmental stages |
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Yoon-Sil Yang, Moon-Suk Kang, Sun-Hee Kim, Su-Yong Eun, Sung-Cherl Jung |
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Department of Physiology, Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Sung-Cherl Jung, Email: jungsc@jejunu.ac.kr
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| Abstract |
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In an early developmental stage within postnatal 3 weeks, neurons in mammalian brains shows dynamic and rapid changes of prolein expression on cellular membrane, related with ion channels and receptors. Using acute slices of rat hippocampi (postnatal 7-21), change of cell capacitance measured electrophysiologically during developmental stages have been studied to find the correlation with resting membrane potentials(RMP), which are decided by ion channel expression on neuronal membrane. The change of RMP showed significant changes to be hyperpolarized during developmental periods. However, the size of neurons was not significantly increased. This result indicates that, in an early developmental stage, developmental processings of neurons may be concentrated for modulating protein/lipid ratio of cellular membranes, rather than physical developments. |
| Key Words:
Resting membrane potential; Whole-cell Capacitance; CA1; Hippocampus; K+channel; Na+ channel |
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