J Med Life Sci > Volume 8(1); 2011 > Article
Journal of Medicine and Life Science 2011;8(1):50-53.
DOI: https://doi.org/10.22730/jmls.2011.8.1.50    Published online December 30, 2011.
Reactive Oxygen Species Scavenging Effects of Vanadyl Sulfate
Areum Daseul Kim, Jin-Won Hyun
School of Medicine, Jeju National University, Jeju, Korea
Correspondence:  Jin-Won Hyun, Email: jinwonh@jejunu.ac.kr
The aim of this study was to investigate the reactive oxygen species(ROS) scavenging effects of vanadyl sulfate. Human Chang liver cells were incubated for 10 passages in media containing deionized distilled water(DDW) and vanadyl sulfate(VOSO4, 52 ㎍/L). VOSO4 at 52 ㎍/L significantly showed free radical scavenging effect of superoxide anion and hydroxyl radicals in cell-tree system. Furthermore, cells treated with VOSO4 at 52 ㎍/L significantly scavenged intracellular ROS compared to cells treated with DDW, as measured by flow cytometry and confocal microscopy after staining with 2’.7'-dichlorodihydrofluorescein diacetate. Our results demonstrated that the antioxidant effects of vanadyl sulfate are mediated by ROS scavenging.
Key Words: Vanadyt sulfate(VOSO4); Human Chang Iiver celis; Reactive oxygen species
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