| 신경세포와 미세신경교세포에서의 궁천피 추출물의 항신경염증 및항산화 효능을 통한 신경보호작용 |
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최 연 희, 정 성 철, 은 수 용 |
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제주대학교 의학전문대학원생리학교실 |
| Anti-neuroinflammatory and anti-oxidative activities of the ethanol extract from Citrus unshiu MARC. |
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Yan Ji Cui, Sung-Cherl Jung, Su- Yong Eun |
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Department of Physiology, Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Su- Yong Eun, Email: syeun@jejunu.ac. kr
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| Abstract |
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Citrus peel extract has shown anti-inflammatory and anti-oxidative effects in several tissues. Therefore ，we investigated whether the ethanol extract from Fruit peel of Citrus unshiu MARC. suppresses brain insult-induced excessive microglial activation and neuronal oxidative stress. Releases of NO，the major inflammatory mediator in microglia，and iNOS mRNA expressions were markedly inhibited in a dose-dependent manner following treatment of the ethanol extract from Citrus unshiu MARC. in LPS-stimulated BV-2 microglia cells. In addition, the extract significantly suppressed LPS-induced mRNA expression of pro-inflammatory cytokine TNF-α IL-lβ and IL-6. On the other hand, the thanol extract exerted intracellular ROS scavenging activities in HT-22 neurons in a dose dependent manner (50-400 ug/ml)， suggesting the potent anti-oxidative stress effects in neurons. Taken together，these results suggest that Citrus unshiu MARC. peel extract has therapeutic potential against neuroinflammation and neurodegeneration via suppression of brain insult-induced microglial activation and neuronal oxidative stresses. |
| Key Words:
Anti-neuroninflammatory， Anti-oxidative, Neurotrophic，Reactive oxygen species, Microglial activation ,
Citrus |
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