J Med Life Sci > Volume 7(1); 2010 > Article
Journal of Medicine and Life Science 2010;7(1):110-113.
DOI: https://doi.org/10.22730/jmls.2010.7.1.110    Published online June 30, 2010.
Detection of ehrlichial infection by using polymerase chain reaction
Young-Sang Koh
Department of Microbiology and BK21 Program, Jeju National University School of Medicine, Jeju, Korea
Correspondence:  Young-Sang Koh, Email: yskoh7@jejunu.ac.kr
Abstract
The ehrlichiae are small Gram-negative obligatory intracellular bacteria in the family Anaplasmataceae. Ehrlichiae infection ln an accidental host may result in severe fatal diseases such as human monocytotropic ehrlichiosis (HME), an emerging, tick-borne disease. Using Ehrlichia muris as a model organism, here I show that E. muris can infect bone marrow-derived dendritic cells and macrophages. The ehrlichial infection can be detected by polymerase chain reaction in cultured dendritic cells and macrophages as well as experimentally infected animals.
Key Words: Ehrlichia muris; Bacterial infections; Dendritic cells; Macrophages; Polymerase chin reaction
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