| 사염화탄소로 유도된 간손상에서 볓붉은잎에 의한 inducible nitric oxide synthase 의 발현억제 |
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안미정1, 신태균2 |
1제주대학교 의학전문대학원 해부학교실
2제주대학교 수의과대학 해부학교실 |
| Suppression of inducible nitric oxide synthase (iNOS) expression in carbon tetrachloride (CCI4)-induced acute liver injury by Callophyllis japonica |
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Meejung Ahn1, Taekyun Shin2 |
1Departments of Anatomy, Jeju National University School of Medicine, Jeju, Korea
2Departments of Veterinary Anatomy, Jeju National University College of Veterinary Medicine, Jeju, Korea |
Correspondence:
Taekyun Shin, Email: shint@jejunu.ac.kr
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| Abstract |
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Callophyllis (C.) japonica, which is a red seaweed, have been reported to have hepatoprotective effect on chemical-induced Iiver injury. In this study, we assessed whether oral administration of C. japonica influences the changes of inducible nitric oxide synthase (iNOS) expression in carbon tetrachloride (CCI4)-induced acute liver. The administration of C. japonica (150mg/kg) for 3 days before intraperitoneal injection of CCI4 protected the liver cells from necrotic and fatty changes around the centrilobular lesions histologically. Western blot analysis showed that pre-treatment of C. japonica in CCI4 injected group significantly decreased the level of iNOS expression, compared with those of vehicle treated CCI4-injected group (p<0.05). The immunostaining of iNOS in liver tissues in both groups was matched with Western blot results. Collectively, these finding suggest that increased level of iNOS in CCI4-induced Iiver injury is ameliorated by oral administration of a red seaweed, C. japonica
possibly protecting hepatocytes from Iiver injury. |
| Key Words:
Calfophyllis japonica; Carbon tetrachloride; Red seaweed; iNOS |
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