| Isoacteoside induces heme oxygenase-I via activation of ERK and NF-E2 related factor 2 transcription factor |
|
Dong Ok Ko, Kyoung Ah Kang, Jin Won Hyun |
|
Department of Biochemistry，Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Jin Won Hyun, Email: jinwonh@jejunu.ac.k
|
|
|
| Abstract |
|
Isoacteoside was isolated from Clerdendron trichotomum Thunb that belongs to Verbenaceae family. We found that isoacteoside the heme oxygenase-1 (HO-1) expression in a time dependent manner, Furthermore, isoacteoside increased the expression of NF-E2 regulated factor 2 (Nrf2), which is a transcription factor of HO-1, in a time dependent manner. Moreover, isoacteoside increased the phospho Erk expression. Our data suggested that isoacteoside showed antioxideant effects via Erk activation, induction of Nrf2, and HO-1, in Chinese hamster lung fibroblast cells. |
| Key Words:
Isoacteoside, NF-E2 related factor 2 (Nrf2), Antioxidant effect |
|
PDF Links
Full text via DOI
Download Citation
