| The unseen spread: a case of disseminated tuberculosis with renal manifestation in a healthy adult |
Miyeon Kim1,2 
, Jeong Sub Lee3
, Jeong Rae Yoo1,2
|
1Department of Internal Medicine, Jeju National University Hospital, Jeju, Republic of Korea
2Department of Internal Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea
3Department of Radiology, Jeju National University College of Medicine, Jeju, Republic of Korea |
Correspondence:
Jeong Rae Yoo, Tel: 82-64-717-2286, Fax: 82-64-717-2286, Email: mdyoojr@gmail.com
|
|
Received: 2 September 2024 • Revised: 4 September 2024 • Accepted: 4 September 2024 |
| Abstract |
|
Disseminated tuberculosis (TB), resulting from the hematogenous spread of tubercle bacilli, typically affects immunocompromised individuals, such as those infected with the human immunodeficiency virus. However, risk factors in immunocompetent populations are not well understood. Here, we report a rare case of disseminated TB with CD4+ T-cell depletion in a previously healthy 35-year-old man. The patient presented with a 2-month history of intermittent gross hematuria, dysuria, loose stools, and weight loss. His medical history was unremarkable except for a herpes zoster infection 4 years prior to presentation. Laboratory tests revealed microscopic hematuria and pyuria; however, the urine culture was negative. Urine specimens tested positive for TB-polymerase chain reaction. Abdominal computed tomography revealed a focal filling defect in the left kidney, segmental wall thickening of the terminal ileum, and multiple enlarged lymph nodes with central necrosis. Chest computed tomography revealed active pulmonary TB. Colonoscopy confirmed intestinal TB in the terminal ileum and ileocecal valve, with positive TB-polymerase chain reaction results from sputum and ileal ulcer tissue. The patient was diagnosed with disseminated TB and was treated with standard anti-TB drugs. Although the human immunodeficiency virus test results were negative, the patient’s CD4+ T-cell count was significantly low (278/μL). Follow-up tests after 1 month showed negative TB cultures; however, the patient’s CD4+ T-cell depletion persisted, with counts remaining low after 1 year. This case highlights the rare occurrence of disseminated TB in immunocompetent individuals with CD4+ T-cell depletion and emphasizes the importance of CD4+ T-cell assessment in healthy patients presenting with disseminated TB. |
| Key Words:
Lymphopenia, CD4 lymphocyte count, tuberculosis, renal, T-lymphocytopenia |
|
PDF Links
Full text via DOI
Download Citation
