J Med Life Sci > Volume 15(1); 2018 > Article
Journal of Medicine and Life Science 2018;15(1):6-11.
DOI: https://doi.org/10.22730/jmls.2018.15.1.6    Published online October 30, 2018.
Effect of Active Ingredients in the Citrus Fruits on the Proliferation of Hepatocellular Carcinoma Cells
Soo Jung Kim, Deok Bae Park
Jeju National University School of Medicine
Correspondence:  Deok Bae Park, Email: parkdb@jejunu.ac.kr
Previous studies have suggested that Citrus fruits might suppress the proliferation of various cancer cells. However, little is known about any specific ingredients in the extract of Citrus fruits to exert its anti-proliferative activity in cancer cells. The present study aimed to identify the active ingredients in Citrus fruits to suppress the proliferation of rat hepatocellular carcinoma cells. Among tested compounds, two polymethoxylated flavones(nobiletin and tangeritin) showed significant anti-proliferative activity whereas other compounds(synephrine, rutin, hesperidin) did not. Interestingly, nobiletin as well as tangeritin also decreased the protein amount of gluconeogenic enzymes, PEPCK and G6Pase. The possible involvement of gluconeogenic activity in the proliferation of hepatocellulacarcinoma cells are further to be investigated.

Editorial Office
102, Jejudaehak-ro, Jeju-si, Jeju-do 63243, Republic of Korea
Tel: +82-64-754-8023    E-mail: jmls.jeju@gmail.com                

Copyright © 2024 by Jeju National University Institute for Medical Science.

Developed in M2PI

Close layer
prev next