J Med Life Sci > Volume 11(2); 2014 > Article
Journal of Medicine and Life Science 2014;11(2):132-135.
DOI: https://doi.org/10.22730/jmls.2014.11.2.132    Published online December 18, 2018.
CADASIL 환자에서 소뇌 이환
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Cerebellar involvement in CADASIL
Jung Seok Lee, Chul-hoo Kang, Jung-Hwan Oh, Sook Keun Song, Jay Chol Choi, Sa-Yoon Kang, Ji-Hoon Kang, Bong-hee Jeon, Joon Hyuk Park
Background and Purpose: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small vessel disease caused by mutations in the Notch3 gene. The cerebellum has long been known to be rarely affected by small vessel disease in CADASIL. However, recent studies have shown that cerebral microbleeds are frequently detected and intracranial hemorrhage often occurs in the cerebellum. Our purpose was to examine the influence of epidemiological and vascular risk factors on cerebellar involvement in patients with CADASIL.
The study population comprised 84 patients who underwent brain MRI, including T1-weighted image, susceptibility weighted image (SWI), and fluid attenuated inversion recovery (FLAIR) image. Patients were divided into two groups depending on the presence (CADASIL-C: n=19) or absence (CADASIL-NC: n=65) of cerebellar lesions. The impact of demographical and vascular risk factors on cerebellar lesions was assessed by logistic regression analysis.
Age was an independent risk factor for cerebellar microbleeds in patients with CADASIL. However, there was no significant association between hypertension and cerebellar microbleeds.
Our findings suggest that CADASIL affect cerebellum and cerebellar microbleeds tend to occur in elderly patients with CADASIL.
Key Words: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), cerebellum, age, hypertension
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