| 제주용암해수의 배양액 첨가가 L6 근육세포 포도당수송
활성에 미치는 영향 |
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| Effect of Supplementation of Jeju Magma Seawater on Glucose Transport in
Cultured L6 Skeletal Muscle Cells |
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Gun Jung Ma, Soo Jung Kim, Deok Bae Park |
Correspondence:
Deok Bae Park,
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| Abstract |
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Magma seawater, the underground seawater in Jeju island, contains abundant minerals. Previous studies have suggested the
beneficial effect of deep seawater on hyperlipidemia and cardiovascular diseases. We investigated the in vitro effect of magma
seawater on the glucose transport by skeletal muscle cells, a key regulatory mechanism to maintain blood glucose levels.
Stepwise supplementation of magma seawater (898-1,898 of hardness) to the cell culture mdieum did not affect the viability of
L6 myoblasts. In differentiated L6 skeletal muscle cells, the supplementation of magma seawater elevated the basal- and
insulin-induced glucose transport into cells. Akt and AMPK, insulin-dependent and ?independent signaling pathways to lead
glucose transport respectively, were stimulated by the supplementation of magma seawater to the culture medium. Taken
together, magma seawater of Jeju has a physiological potential to maintain body glucose homeostasis. |
| Key Words:
Magma seawater, glucose transport, skeletal muscle cells |
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