J Med Life Sci > Volume 10(3); 2014 > Article
Journal of Medicine and Life Science 2014;10(3):209-213.
DOI: https://doi.org/10.22730/jmls.2014.10.3.209    Published online February 28, 2014.
Expression of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinase-1 in Carotid Stenosis
Young-Hee Maeng1, Jee Won Chang2, Jay Chol Choi3, Su Wan Kim2
1Department of Pathology, School of Medicine, Jeju National University, Jeju, Korea
2Department of Thoracic and Cardiovascular surgery, School of Medicine, Jeju National University, Jeju, Korea
3Department of Neurology, School of Medicine, Jeju National University, Jeju, Korea
Correspondence:  Jee Won Chang, Email: jeewon71@naver.com
Received: 21 January 2014   • Revised: 28 January 2014   • Accepted: 4 February 2014
It is still controversial whether the specific subtypes of matrix metalloproteinases are related to clinical characteristics in carotid stenosis patients. Carotid atherosclerotic plaques were obtained from 34 patients, 21 males and 13 females with mean age of 71.1. Carotid endarterectomy was performed under the monitoring of EEG and carotid stump pressure. Expression of matrix metalloproteinase-2, 8, 9, and tissue inhibitor of metalloproteinase-1 in the atherosclerotic plaque was assessed by immunohistochemical slides stained with primary antibodies semi-quantitatively. Twenty patients (58.8%) were symptomatic stenosis and 15 (44.1%) had stable plaques without evidence of fibrous cap rupture. Strong stain (degree 3) of matrix metalloproteinase-2 and 9 was dominant in asymptomatic group (P= 0.026 and P= 0.0007, respectively). Strong stain of matrix metalloproteinase-2 was dominant in stable plaque group (P= 0.026). Specific subtypes of matrix metalloproteinases can be related to clinical characteristics such as symptoms or plaque morphology.
Key Words: Atherosclerosis Carotid Arteries Matrix metalloproteinases

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